Autoimmune neutropaenia complicating Sjögren's Syndrome: haematological and clinical improvement with granulocyte colony stimulating factor

Rheumatology
Case Report
10.1102/1470-5206.2007.0012
7
39-41
Autoimmune neutropaenia complicating Sjögren's Syndrome: haematological and clinical improvement with granulocyte colony stimulating factor

Connective tissue diseases are associated with granulocyte-specific autoantibodies and autoimmune neutropaenia. Reduced levels of circulating neutrophils may predispose to recurrent infections, particularly of the respiratory tract, although severe and opportunistic infections have also been reported. There is only one previous description of the use of granulocyte colony stimulating factor (GCSF) in Sjögren's Syndrome complicated by autoimmune neutropaenia, reporting poor response and tolerability. We present here the successful use of GCSF in a 42-year-old woman with Sjögren's Syndrome, autoimmune neutropaenia and chronic mastoiditis.

application/pdf iconView article
55.88 KB

Editor-in-Chief

Frank Cross
Consultant Vascular and General Surgeon
The London Clinic, UK

Editors

Neil Barnes
Consultant Physician
Barts Health NHS Trust, London, UK
Ali Jawad
Professor of Rheumatology
Barts Health NHS Trust, London, UK

Join our newsletter

* indicates required

view counter
view counter
view counter
view counter
view counter