Inflammatory oncotaxis in cholangiocarcinoma

HPB Surgery; Oncology
Case Report
10.1102/1470-5206.2013.0011
13
57-62
Inflammatory oncotaxis in cholangiocarcinoma

Inflammatory oncotaxis is the term used to describe the phenomenon whereby mechanically injured tissues are predisposed to the development of metastases. Normal tissue injury elicits an inflammatory response, and it has been found that the microenvironment created is similar to that of the tumour microenvironment. Subsequently tumours have often been described as “wounds that do not heal”. Here we present the first reported case of inflammatory oncotaxis in a patient with cholangiocarcinoma in whom the cancer preferentially metastasized to the site of a healing fracture; the underlying mechanisms are discussed.

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Editor-in-Chief

Frank Cross
Consultant Vascular and General Surgeon
The London Clinic, UK

Editors

Neil Barnes
Consultant Physician
Barts Health NHS Trust, London, UK
Ali Jawad
Professor of Rheumatology
Barts Health NHS Trust, London, UK

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