Oncology

Inflammatory oncotaxis is the term used to describe the phenomenon whereby mechanically injured tissues are predisposed to the development of metastases. Normal tissue injury elicits an inflammatory response, and it has been found that the microenvironment created is similar to that of the tumour microenvironment. Subsequently tumours have often been described as “wounds...
(Vol 13 p 57-62, HPB Surgery; Oncology: 22 July 2013)
Nodular sclerosing Hodgkin disease stage IV according to the Ann Arbor classification was diagnosed in a 30-year-old nulliparous woman. Because management required the use of a chemotherapy regimen with a high risk of secondary infertility, ovarian cryopreservation was realized by single-site laparoscopic unilateral oophorectomy. The single-site approach can limit...
(Vol 13 p 1-3, Gynaecology; Oncology: 6 March 2013)
Solitary fibrous tumour is a rare spindle cell neoplasm of uncertain histogenesis and unpredictable biological behaviour, which was first described in the pleura and subsequently in many extrapleural locations. The clinical, radiologic and histologic features of a case of pelvic extraperitoneal solitary fibrous tumour in a young male are presented.
(Vol 11 p 92-97, General surgery; Oncology: 6 December 2011)
Liposarcoma is a mesenchymal neoplasm of uncertain pathogenesis. It is the second most common soft tissue sarcoma, found uncommonly in the breast, and constitutes less than 1% of all malignant breast tumors. We report a case of a 50-year-old woman with a pleomorphic type liposarcoma of the breast.
(Vol 11 p 87-91, Breast surgery; General surgery; Oncology; Pathology; Radiology: 17 October 2011)
This is the case of a 7-year-old girl with a history of migraine headaches who presented with a head tilt to the left and worsening headaches. Papilloedema was found on ophthlamoscopy. She had an intermittent history of migraine-type headaches for the past year. Oral naproxen 375 mg twice daily provided some relief of the headaches initially but they slowly worsened and...
(Vol 11 p 81-86, Radiology; Oncology; Paediatrics: 17 October 2011)
Febrile illness has a broad differential diagnosis, particularly among persons infected with human immunodeficiency virus (HIV). Infectious complications of immunodeficiency must always be high on this differential, but clinicians must also consider HIV-associated malignancies as an explanation for fever in this population. We present the case of a 48-year-old man with...
(Vol 11 p 34-36, Critical Care; Infection and Immunity; Oncology; Virology: 6 April 2011)
Breast hamartoma is an uncommon pathological entity. It is exceedingly rare to find ductal carcinoma in situ or invasive carcinoma within a breast hamartoma. We report one such case treated at our unit.
(Vol 10 p 113-116, Breast Surgery; Oncology: 20 December 2010)
Neurocristic hamartoma results from the aberrant development of cells derived from the neural crest. It is a type of dermal melanocytosis. These tumours may contain neuro-sustentacular and fibrogenic components in addition to a dermal melanocytic component. The elements within these tumours reflect the spectrum of differentiation that results from migration of neural...
(Vol 10 p 91-94, Oncology: 10 November 2010)
We describe central nervous system blast crisis on a background of chronic myeloid leukaemia in remission in a 70-year-old man. After successful elimination of blasts in the cerebrospinal fluid, this patient received craniospinal irradiation (CSI). He remains well 30 months after CSI and has no significant long-term toxicity. CSI is usually reserved for patients under the...
(Vol 10 p 89-90, Oncology: 25 October 2010)
A 72-year-old male was admitted with painful swelling of his left arm. Physical examination revealed supraclavicular lymphadenopathy with swollen left arm and a stony-hard prostate on rectal examination. Routine blood tests were normal. Doppler test showed deep vein thrombosis in the left arm. Tomography of chest, abdomen and pelvis showed generalized lymphadenopathy,...
(Vol 10 p 67-70, Oncology: 22 October 2010)
We present a case of a 59-year-old gentleman with myasthenia gravis and metastatic renal cell carcinoma that resolved on sunitinib. The clear temporal relationship between the patient receiving sunitinib for renal cell carcinoma and the resolution of his myasthenia gravis suggests that the improvement was due either to a paraneoplastic condition responding to treatment of...
(Vol 10 p 42-45, Neurology; Oncology; Urology: 22 July 2010)
A woman with known adenocarcinoma of the right parotid gland presented with bony metastasis in her left proximal femur. This was histologically confirmed and the patient underwent prophylactic intramedullary nail and hip screw fixation of her left proximal femur. This represents the first report of adenocarcinoma of parotid origin metastasising to a long bone in an adult.
(Vol 9 p 59-62, Oncology, Orthopaedic surgery: 22 July 2010)
Acquired factor VIII inhibitor is a rare occurrence and may cause severe bleeding by interfering with the coagulation cascade. We report an interesting case of a 59-year-old white man with an acquired factor VIII inhibitor and lupus anticoagulant. Clinical findings included large hemorrhagic areas of the extremities, a prolonged activated partial thrombin time (aPTT) that...
(Vol 10 p 19-24, Haematology; Oncology: 6 April 2010)
A rare case of local recurrence of a high-grade osteosarcoma of the pelvis is described, 19 years after initial presentation, highlighting the need for continued long-term follow-up of patients with osteosarcoma. We review the literature concerning osteosarcoma of the pelvis, local recurrence and treatment with custom-made hemipelvic replacements.
(Vol 10 p 8-12, Oncology; Orthopaedics: 16 February 2010)
A case is described involving a 71-year-old hirsute woman with a growing adrenal tumor and a high serum testosterone level, which did not normalize after adrenalectomy. Following this she was found to have a testosterone-producing ovarian Leydig cell tumor. This case provides key features that can help distinguish adrenal and ovarian causes of hirsutism.
(Vol 9 p 42-44, Oncology: 17 November 2009)
We report the case of 58-year-old gentleman with pancreatic masses, possibly of neuroendocrine origin, with the history of renal carcinoma, primary hyperparathyroidism and pituitary cyst. Histological analysis after pancreatectomy revealed metastases from renal cancer. This unusual case illustrates the challenging differential diagnosis between multiple endocrine...
(Vol 9 p 14-17, Endocrinology, Oncology: 28 May 2009)
Metastatic involvement resulting in voice alteration may occur from vocal cord infiltration or recurrent laryngeal nerve involvement. We present a case of metastatic prostate adenocarcinoma to the left infrahyoid neck compressing the larynx resulting in hoarseness. A case report with one-year follow-up is presented. The patient is a 65-year-old male with hoarseness and a...
(Vol 5 p 28-33, Oncology, Ear, nose and throat: May 2005)
Secondary involvement of the urinary bladder in non-Hodgkin’s lymphoma is relatively common, but primary malignant lymphomas of this organ remain exceedingly rare. We report a case presenting atypically with renal colic and briefly review the relevant literature.
(Vol 4 p 7-9, Urology, oncology: May 2004)
The internal fixation of fractures is associated with a risk of infection. Open fractures in particular are susceptible to such infection. Treatment is difficult and patients can develop a chronic osteomyelitis. We present the case of a patient who developed chronic osteomyelitis with a persistent discharging sinus following internal fixation of an open fracture of tibia...
(Vol 4 p 4-6, Orthopaedics and Oncology: March 2004)
Foster Kennedy syndrome (FKS) is rare. It is characterised by the presence of ipsilateral optic atrophy, contralateral papilloedema and ipsilateral anosmia. Since its first description in 1911, it has never been reported in oligodendroglioma. Here we discuss the first case of a patient with oligodendroglioma presenting with FKS.
(Vol 3 p 27-30, Neurosurgery and oncology: January 2004)
Centripetal enhancement of liver lesions on MRI scanning is an almost specific finding in the diagnosis of benign hemangiomata. The ability of MRI to produce higher temporal resolution of dynamic measurements shows that malignant liver lesions can also demonstrate centripetal enhancement. We report here a case of a malignant gastrointestinal stromal tumor (GIST) with a...
(Vol 3 p 8-12, Oncology and Radiology: June 2003)
A number of paraneoplastic neurological syndromes have been described in association with small cell lung carcinoma and, less commonly, with other malignancies. We describe here the case of a 58-year-old woman with paraneoplastic limbic encephalitis (PLE) complicating squamous cell carcinoma of the lung.She presented with subacute cognitive decline, particularly memory...
(Vol 2 p 46-49, Neurology, Oncology: August 2002)
Relapse of squamous cell carcinomas usually occurs in a predictable pattern. We present two patients with rare metastases. The first developed peritoneal disease without evidence of intra-thoracic spread due to a laryngeal cancer. The second, a patient with a vulval squamous tumour was presented with distant disease following foot pain.
(Vol 2 p 43-45, Oncology: July 2002)
ACC is an unusual pulmonary neoplasm, accounting for 0.09%–0.2% of all lung cancers. It is a low-grade tumour with unusual histological features and rarely metastasises outside the lungs. We describe a case with bilateral renal metastases. We discuss the clinical and histological features, and the implications for its treatment.
(Vol 2 p 40-42, Respiratory Medicine; Oncology: July 2002)

Editor-in-Chief

Frank Cross
Consultant Vascular and General Surgeon
The London Clinic, UK

Editors

Neil Barnes
Consultant Physician
Barts Health NHS Trust, London, UK
Ali Jawad
Professor of Rheumatology
Barts Health NHS Trust, London, UK

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