Pathology

It is uncommon in clinical practice to discover cancer as either a metastasis within soft tissue or containing heterotopic bone formation. These rarities are documented primarily through case reports in the literature. This report describes a patient with colon cancer whose painful wrist lesion was proven to exhibit both of these unusual features. It is important to...
(Vol 14 p 16-20, General Surgery; Orthopaedics; Pathology; Radiology: 3 September 2014)
Multiple pathologic fractures in a patient with sickle cell disease is rare; bone involvement is well documented in this disease, however multiple pathologic fractures as a complication are uncommon. We present a case involving a 19-month-old boy known to have sickle cell disease who developed multiple pathologic fractures as a complication of his disease. The patient was...
(Vol 13 p 63-68, Haematology; Orthopaedics; Paediatrics; Pathology; Radiology: 22 July 2013)
We report an interesting complex CFTR gene mutation in a patient with cystic fibrosis. It is an insertion combined with a deletion that spans an exonic splice site, causes a frameshift and could affect splicing. This rare mutation poses a challenge to provide correct nomenclature and to interpret its clinical significance.
(Vol 12 p 36-39, Pathology; Paediatrics; Respiratory Medicine: 10 August 2012)
We present a case of a 58-year-old woman with a posterior neck mass who underwent fine-needle aspiration of the lesion, with initial cytopathologic evaluation being consistent with metastatic squamous cell carcinoma. However, following excisional biopsy of the tumor, histopathologic evaluation revealed a pilomatricoma. Appreciation of the difficulty in cytologic...
(Vol 12 p 17-22, Head and neck surgery; General surgery; Paediatric surgery; Pathology: 27 April 2012)
A 76-year-old man presented with a mass on his right leg. He had sustained an open fracture of the right tibia 58 years ago. Imaging showed a well-circumscribed fusiform calcified mass and atrophy of the right calf muscles. The findings and the history led to the diagnosis of calcific myonecrosis.
(Vol 12 p 10-13, Pathology; Radiology; Trauma: 5 March 2012)
Liposarcoma is a mesenchymal neoplasm of uncertain pathogenesis. It is the second most common soft tissue sarcoma, found uncommonly in the breast, and constitutes less than 1% of all malignant breast tumors. We report a case of a 50-year-old woman with a pleomorphic type liposarcoma of the breast.
(Vol 11 p 87-91, Breast surgery; General surgery; Oncology; Pathology; Radiology: 17 October 2011)
Systemic amyloidosis secondary to myeloma is an uncommon condition that often has an insidious onset and poses as a diagnostic challenge due to the lack of typical presenting symptoms and signs. Prompt diagnosis of amyloidosis and appropriate referral have the potential to improve outcome for these patients. Here, we report the unusual case of a man whose primary...
(Vol 11 p 56-59, Haematology; Histopathology; Nephrology; Neurology; Pathology; Radiology: 18 July 2011)
Systemic amyloidosis secondary to myeloma is an uncommon condition that often has an insidious onset and poses as a diagnostic challenge due to the lack of typical presenting symptoms and signs. Prompt diagnosis of amyloidosis and appropriate referral have the potential to improve outcome for these patients. Here, we report the unusual case of a man whose primary...
(Vol 11 p 56-59, Haematology; Histopathology; Nephrology; Neurology; Pathology; Radiology: 18 July 2011)
We describe a case of very late stent thrombosis (ST) in a patient presenting with hematemesis while taking aspirin and oral anticoagulation therapy (OAC). This case shows that the management of patients with an indication for OAC who undergo percutaneous coronary intervention with drug-eluting stent (DES) implantation is challenging because of the need to balance the...
(Vol 11 p 48-52, Cardiology; Emergency Medicine; Gastroenterology; Haematology; Histopathology; Pathology: 18 July 2011)
We describe a case of very late stent thrombosis (ST) in a patient presenting with hematemesis while taking aspirin and oral anticoagulation therapy (OAC). This case shows that the management of patients with an indication for OAC who undergo percutaneous coronary intervention with drug-eluting stent (DES) implantation is challenging because of the need to balance the...
(Vol 11 p 48-52, Cardiology; Emergency Medicine; Gastroenterology; Haematology; Histopathology; Pathology: 18 July 2011)
Spontaneous renal haemorrhage secondary to renal angiomyolipoma, or Wunderlich syndrome, is rare. Renal angiomyolipomata are composed of abnormal vasculature, smooth muscle and adipose tissue. They are more likely to be symptomatic if they are larger than 4 cm, presenting with a history of flank pain, a palpable mass and rarely gross haematuria. Our case illustrates a...
(Vol 10 p 117-119, General Surgery; Histopathology; Urology: 20 December 2010)
Carcinoid tumours are unique neuroendocrine neoplasms, displaying low-grade malignant potential and arising frequently within the gastrointestinal tract and respiratory tree. Primary carcinoid arising within the renal system is uncommon, whilst carcinoid tumour arising within a horseshoe kidney is rare. We describe a case of primary renal carcinoid occurring within a...
(Vol 10 p 46-50, Histopathology; Urology: 22 July 2010)
A case of cutaneo-cutaneous fistula superior to the external auditory canal extending from the mastoid skin to the skin over the zygoma is reported. The adult patient presented with recurrent discharge and swelling of the skin over the zygoma and mastoid bones. Definitive treatment was in the form of complete excision of the fistula tract.
(Vol 9 p 54-57, ENT/head and neck surgery; Microbiology: 24 December 2009)
We report on an 81-year-old male with bilateral septic arthritis of the knee joints, who was treated with multiple joint washouts and intravenous antibiotics. As far as we know, there has been no case report in the English literature, on bilateral septic arthritis of the knee secondary to group G β-haemolytic streptococcal endocarditis.
(Vol 8 p 28-30, Cardiology; Microbiology; Orthopaedic Surgery; Infection and Immunity: 29 September 2008)

Editor-in-Chief

Frank Cross
Consultant Vascular and General Surgeon
The London Clinic, UK

Editors

Neil Barnes
Consultant Physician
Barts Health NHS Trust, London, UK
Ali Jawad
Professor of Rheumatology
Barts Health NHS Trust, London, UK

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